Opoisomerases are enzymes that act to relax supercoiling, a form of built-up strain in DNA - see one of our previous covers for Nature in 2005. This is a prime example of what these enzymes can actually do: as illustrated on the cover, positive DNA supercoils accumulate due to the action of the drug (shown red) Such overwinding of the DNA hinders an advancing DNA polymerase and may play a role in the stalling or collapse of a replication fork, ultimately leading to cell death. This may be an effective way to stop unwanted cell replication.
A nice detail is the background: this is an actual image of the yeast used by the researchers in the lab. We love to incorporate the real imagery as much as possible in the final result.
Tremani specialises in discovering your story, and visualising the essence in an image or even an animation. Quickly and on target. If you have your article pending or even approved and waiting for a publication date, now is the time to try and make the cover! Do talk to us to find out what can be done.Contact us